发明名称 |
BIOMATERIALS CARRYING CYCLODEXTRINES HAVING IMPROVED ABSORPTION PROPERTIES AND USED FOR THE PROGRESSIVE AND DELAYED RELEASE OF THERAPEUTIC MOLECULES |
摘要 |
<p>A method for preparing a biomaterial containing at least one bioactive molecule from a base biomaterial, comprising the following successive operations carried out on the base biomaterial: a) application of a solid mixture of: cyclodextrin(s) and/or cyclodextrin derivative(s) and/or cyclodextrin inclusion complex(es) and/or cyclodextrin derivative inclusion complex(es), at least one poly(carboxylic) acid, and optionally a catalyst; b) heating at a temperature between 100° C. and 200° C. for a period of 1 to 60 minutes; c) washing with water; d) drying, wherein at least one bioactive agent is incorporated in the biomaterial by impregnation of the biomaterial after the drying step in a concentrated solution of the bioactive agent.</p> |
申请公布号 |
EP1824531(A1) |
申请公布日期 |
2007.08.29 |
申请号 |
EP20050817573 |
申请日期 |
2005.11.15 |
申请人 |
UNIVERSITE DES SCIENCES ET TECHNOLOGIES DE LILLE SAIC |
发明人 |
MARTEL, BERNARD;BLANCHEMAIN, NICOLAS;BOSCHIN, FRANCOIS;HAULON, STEPHAN;DELCOURT-DEBRUYNE, ELISABETH;MORCELLET, MICHEL;HILDEBRAND, HARTMUT, FRIEDRICH |
分类号 |
A61L27/54;A61K47/40;A61K47/48;A61L27/34;A61L27/56;A61L29/08;A61L29/14;A61L29/16;A61L31/10;A61L31/14;A61L31/16;C08B37/00 |
主分类号 |
A61L27/54 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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