发明名称 |
THERAPEUTIC PEPTIDE FORMULATIONS FOR COATING MICRONEEDLES WITH IMPROVED STABITITY CONTAINING AT LEAST ONE COUNTERION |
摘要 |
Compositions of and methods for formulating and delivering peptide, polypeptide and protein therapeutic agent formulations having enhanced physical stability using at least one counterion, and wherein fibril formation is minimized and/or controlled, to yield a consistent and predictable composition viscosity. The compositions of and methods for formulating and delivering peptide, polypeptide and protein therapeutic agents of the present invention further facilitate their incorporation into a biocompatible coating which can be employed to coat a stratum-corneum piercing microprojection, or a plurality of stratum-corneum piercing microprojections of a delivery device, for delivery of the biocompatible coating through the skin of a subject, thus providing an effective means of delivering the peptide therapeutic agents. The preferred counterions are acetate and chloride. |
申请公布号 |
WO2006079019(A3) |
申请公布日期 |
2006.12.21 |
申请号 |
WO2006US02262 |
申请日期 |
2006.01.19 |
申请人 |
ALZA CORPORATION;CORMIER, MICHEL, J., N.;AMERI, MAHMOUD |
发明人 |
CORMIER, MICHEL, J., N.;AMERI, MAHMOUD |
分类号 |
A61K9/30;A61K38/00;A61K38/25;A61K47/02;A61K47/12 |
主分类号 |
A61K9/30 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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