摘要 |
PCT No. PCT/US86/01275 Sec. 371 Date Mar. 6, 1987 Sec. 102(e) Date Mar. 6, 1987 PCT Filed Jun. 10, 1986 PCT Pub. No. WO87/00519 PCT Pub. Date Jan. 29, 1987.Disclosed is a process for the production of acids of the formula <IMAGE> (IV) wherein R is 2-fluoro-4-(1,1'-biphenyl), 4-(2-methylpropyl)phenyl, 6-methoxy-2-napthyl, 3-benzophenyl, 4-(2-thienylcarbonyl)-phenyl or 7-chlorocarbazole-3-yl which comprises contacting an organometallic compound of the formula R-M-R1 (G) with an allyl halide of the formula <IMAGE> (V) to produce an olefin of the formula <IMAGE> (II) ozonolysis of the olefin (II) to produce an aldehyde of the formula <IMAGE> (III) which is oxidized either directly to the acid (IV) or via a bisulfite adduct of the formula <IMAGE> (VI)
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