Benzodiazepine compounds and their use as pharmaceuticals.

摘要

Pharmaceutical thiazolo-[1,5]benzodiazepines of the formula <CHEM> in which R<1>, R<2>, R<3> and R<4> are independently hydrogen, C1-4 alkyl, C2-4 alkenyl, halogen, C1-4 haloalkyl, nitro, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio or phenylsulphonyl; in which R<5> is a group of the formula formula <CHEM> where R<7> is hydrogen, C1-6 alkyl, C3-7 cycloalkyl C1-4 alkyl, benzyl or ZO-C2-6 alkyl where Z is hydrogen or an acyl group, R<8> is hydrogen or C1-4 alkyl and n is 0 or 1, provided that when R<7> is hydrogen n is 0; in which R<6> is hydrogen, C1-10 alkyl, C3-7 cycloalkyl, C3-7 cycloalkyl C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy or C1-4 alkylthio; and in which <CHEM> represents a thiazole ring selected from <CHEM> and acid addition salts thereof. The compounds have central nervous system activity.