| 摘要 |
The present invention relates to the use of an alginate for the production of a cross-linked, highly pure and high-molecular alginate solution (SoI) as a filler material for medical purposes, particularly for (dermatological) surgery, or in cosmetics for increasing volume, wherein the alginate in the non cross-linked, highly pure and high-molecular alginate solution (SoI) is present in a concentration of 0.5-2.5% (w/v) alginate solids content and wherein the non-cross-linked, highly pure and high-molecular alginate solution is injected in vivo and spontaneously results in in-situ Ca2+ cross-linking without exogenous addition of a cross-linking agent. The present invention further describes the use of said non cross-linked, highly pure and high-molecular alginate solution (SoI) for the treatment of skin wrinkles, for example on the hand, the face or the chest area, or of volume deficits, for increasing volume, for example with (HIV-induced) lipoatrophy, of the breast and for the treatment of select diseases, for example gastroesophageal reflux disease, urinary incontinence or vesicoureteral reflux disease, by injection under the corresponding sphincter muscles, or for use in reconstructive surgery, particularly for cosmetic reasons.
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