| 摘要 |
Use of at least one polypeptide (A), containing at least fragment of a protein (B) selected from 28 sequences described in the specification, or having at least 70%, preferably 98% homology, to (B) or a fragment of one of the stated proteins, for detecting, preventing or treating a degenerative, neurological and/or auto-immune disease. The sequences belong to the perlecan, precursor of the retinol-binding plasma protein, precursor of the ganglioside GM2 activator, calgranulin B or saposin B protein families. Independent claims are also included for the following: (a) use of nucleic acids (C) that encode (A), or of the ligands (L) of (A) for detecting, preventing or treating a degenerative, neurological and/or autoimmune disease as for (A); (b) use of (A) for preparation of immunogenic peptides; (c) method for detecting (A), associated with a disease, by contacting (A) with (L) to form a complex of a complex or vice versa; (d) polypeptide (A1) with a 193 amino acid sequence described in the specification, or fragments of it, provided these include at least one mutation relative to another 193 amino acid sequence (8) described in the specification; (e) use of (A1) in the same ways as (A); (f) nucleic acid (C1) encoding (A1); (g) use of (C1) in the same ways as (C); (h) method for detecting (A) and (A1) by mass spectrometry; (i) diagnostic and prognostic method based on measuring at least one (A); (j) use of (A), (C) or recombinant proteins encoded by (C), for testing the efficacy of therapeutic agents or for producing a pharmaceutical composition; and (k) use of lycorin to produce a composition for preventing or treating a degenerative, neurological and/or autoimmune disease. ACTIVITY : Antineurodegeneration; Immunomodulatory. MECHANISM OF ACTION : Vaccine; Gene therapy. |
