发明名称 |
PROCESSES FOR THE PREPARATION OF THREO-1,2-EPOXY-3-AMINO-4-PHENYLBUTANE DERIVATIVES |
摘要 |
The present invention provides a production method of high quality threo-1,2-epoxy-3-amino-4-phenylbutane derivatives (1) on a commercial scale in a simple, easy and efficient manner and with very high productivity, which comprises treating a threo-1-halo-2-hydroxy-3- amino-4-phenylbutane derivative (2) with a base in a polar organic solvent or a solvent composed of a polar organic solvent and water, and adding the resulting reaction mixture to water to thereby cause the resulting threo-1,2-epoxy-3-amino-4- phenylbutane derivative (1) to crystallize out.
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申请公布号 |
CA2325919(C) |
申请公布日期 |
2009.07.21 |
申请号 |
CA20002325919 |
申请日期 |
2000.01.31 |
申请人 |
KANEKA CORPORATION |
发明人 |
UEDA, YASUYOSHI;MAEHARA, KATSUJI;TOKUDA, YUKINORI;MURAO, HIROSHI |
分类号 |
C07D301/26;C07D301/32;C07D303/36 |
主分类号 |
C07D301/26 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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