发明名称 |
METHODS FOR IDENTIFYING LIGANDS THAT TARGET NUCLEIC ACID MOLECULES AND NUCLEIC ACID STRUCTURAL MOTIFS |
摘要 |
Disclosed are methods for identifying a nucleic acid (e.g., RNA, DNA, etc.) motif which interacts with a ligand. The method includes providing a plurality of ligands immobilized on a support, wherein each particular ligand is immobilized at a discrete location on the support; contacting the plurality of immobilized ligands with a nucleic acid motif library under conditions effective for one or more members of the nucleic acid motif library to bind with the immobilized ligands; and identifying members of the nucleic acid motif library that are bound to a particular immobilized ligand. Also disclosed are methods for selecting, from a plurality of candidate ligands, one or more ligands that have increased likelihood of binding to a nucleic acid molecule comprising a particular nucleic acid motif, as well as methods for identifying a nucleic acid which interacts with a ligand. |
申请公布号 |
WO2008066873(A3) |
申请公布日期 |
2009.04.09 |
申请号 |
WO2007US24546 |
申请日期 |
2007.11.29 |
申请人 |
THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK;CHILDS-DISNEY, JESSICA, L.;DISNEY, MATTHEW, D. |
发明人 |
CHILDS-DISNEY, JESSICA, L.;DISNEY, MATTHEW, D. |
分类号 |
C40B30/04 |
主分类号 |
C40B30/04 |
代理机构 |
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地址 |
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