| 发明名称 |
CHK1 SUPPRESSES A CASPASE-2 APOPTOTIC RESPONSE TO DNA DAMAGE THAT BYPASSES P53, BCL-2 AND CASPASE-3 |
| 摘要 |
<p>The invention describes methods that are useful for treating cancer by administering a Chk1 inhibitor which can induce apoptosis in p53-defective cells when combined with a chemotherapy and/or radiotherapy. Methods for screening candidates for a Chk1 inhibitor-based cancer treatment regimen are also described.</p> |
| 申请公布号 |
EP2247953(A2) |
申请公布日期 |
2010.11.10 |
| 申请号 |
EP20090708478 |
申请日期 |
2009.02.04 |
| 申请人 |
DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
LOOK, A., THOMAS;SIDI, SAMUEL |
| 分类号 |
G01N33/574 |
主分类号 |
G01N33/574 |
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