APOPTOTIC ANTI-IGE ANTIBODIES

摘要

PROBLEM TO BE SOLVED: To provide apoptotic anti-IgE antibodies usable for treating IgE-mediated disorders, nucleic acids encoding them and therapeutic compositions thereof.SOLUTION: The present invention provides an anti-IgE/Ml' antibody that specifically binds the Ml' segment of IgE and induces apoptosis in IgE-producing B-cells. In a specific aspect, the antibody specifically depletes IgE-producing B-cells. In another specific aspect, the antibody reduces total serum IgE. In yet another specific aspect, the antibody reduces both total serum and serum-free IgE. In a still further specific aspect, the antibody binds to IgE that is human, rhesus monkey and cynomolgus monkey in origin. In a still further specific aspect, the antibody is chimeric. In a still further specific aspect, the antibody is humanized. In a still further aspect, the antibody is human.