发明名称 Fused tricyclic aryl compounds useful for the treatment of viral diseases
摘要 The present invention relates to novel Fused Tricyclic Aryl Compounds, compositions comprising at least one Fused Tricyclic Aryl Compound, and methods of using the Fused Tricyclic Aryl Compounds for treating or preventing HCV infection in a patient.
申请公布号 US9139569(B2) 申请公布日期 2015.09.22
申请号 US201013320427 申请日期 2010.05.12
申请人 Merck Sharp & Dohme Corp. 发明人 Rosenblum Stuart B.;Chen Kevin X.;Kozlowski Joseph A.;Njoroge F. George;Coburn Craig A.
分类号 C07D493/04;C07D491/044;C07D487/04;C07D471/04;C07D403/14;C07C403/04 主分类号 C07D493/04
代理机构 代理人 Bergman Jeffrey P.;Ginkel Laura M.
主权项 1. A compound having the formula: or a pharmaceutically acceptable salt thereof, wherein each dotted line represents an optional and additional bond, such that only one optional and additional bond can be attached to each of Y1 and Y2, and wherein: A is imidazole or benzimidazole, wherein said imidazole group or said benzimidazole group can be optionally and independently substituted on one or more ring nitrogen atoms with R1 and on one or more ring carbon atoms with R3; D is imidazole or benzimidazole, wherein said imidazole group or said benzimidazole group can be optionally and independently substituted on one or more ring nitrogen atoms with R2 and on one or more ring carbon atoms with R4; L1 and L2 are each independently selected from a bond, C1-C4 alkylene, —NH—, —C(O)—, —NHC(O)— and —S(O)2—; the group:is selected from: each occurrence of R1 is independently —C1-C6 alkyl, —C1-C6 haloalkyl, -(3 to 7-membered cycloalkyl) or -(4 to 7-membered heterocycloalkyl); each occurrence of R2 is independently —C1-C6 alkyl, —C1-C6 haloalkyl, -(3 to 7-membered cycloalkyl) or -(4 to 7-membered heterocycloalkyl); R3 and R4 are each independently selected from: each occurrence of R5 is independently: each occurrence of Ra is independently H, C1-C6 alkyl, haloalkyl, cycloalkyl or aryl; and each occurrence of Rb is independently C1-C6 alkyl, such that the compound of formula (I) contains at least one R3 group and at least one R4 group.
地址 Rahway NJ US