| 摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to 4-pyridinone compounds of formula I:, where Y represents CN, C-alkinyl, (CH)C-heterocyclyl, (CH)C-aryl, with said alkinyl, heterocyclyl and aryl being substituted with 1-3 groups R; X, Xand Rindependently represent hydrogen, halogen, CN, C-alkyl, with said alkyl being optionally substituted with 1-3 groups R; Rrepresents H, OH, C-alkyl, (CH)C-cycloalkyl, (CH)C-heterocyclyl, (CH)C-aryl, with said aryl and heterocyclyl being optionally substituted with 1-3 groups R; Rrepresents C-alkyl, halogen, CF, OCF, NRC(O)R, C(O)N(R), C(O)R, CN, NHSOR, OR, (CH)C-heterocyclyl, (CH)C-aryl, with said alkyl, heterocyclyl and aryl being optionally substituted with 1-3 groups R; Rrepresents halogen; and n represents integer number from 0 to 2, which are catechol-O-methyltransferase (COMT) inhibitors.EFFECT: obtaining 4-pyridinone compounds.14 cl, 1 tbl, 16 ex |
