摘要 |
The present invention provides compounds of Formula (I-A), (I-B), and (I-C), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof. Compounds of the present invention are useful for inhibiting Myc (e.g., c-Myc) activity. The present invention further provides methods of using the compounds described herein for treating Myc-mediated disorders (e.g., cancer and other proliferative diseases). The present invention also provides assays for identifying Myc inhibitors. |
申请人 |
DANA-FARBER CANCER INSTITUTE, INC.;WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH |
发明人 |
BRADNER, JAMES, E.;MCKEOWN, MICHAEL, R.;RAHL, PETER, B.;YOUNG, RICHARD, A.;MARINEAU, JASON, J. |