| 发明名称 | Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydrocodone, prodrugs, methods of making and use thereof | ||
| 摘要 | The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs/compositions of hydrocodone, including benzoates and heteroaryl carboxylic acids, which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology. | ||
| 申请公布号 | US9132125(B2) | 申请公布日期 | 2015.09.15 |
| 申请号 | US201414557570 | 申请日期 | 2014.12.02 |
| 申请人 | KemPharm, Inc. | 发明人 | Mickle Travis;Guenther Sven;Mickle Christal;Chi Guochen;Kanski Jaroslaw;Martin Andrea K.;Bera Bindu |
| 分类号 | A61K45/06;A61K31/485;A61K47/48;C07D491/08;C07D489/04;A61K31/167 | 主分类号 | A61K45/06 |
| 代理机构 | McAndrews, Held & Malloy, Ltd. | 代理人 | McAndrews, Held & Malloy, Ltd. |
| 主权项 | 1. A composition comprising acetaminophen and a conjugate, wherein the conjugate is benzoate-hydrocodone (Bz-HC) having the following structure: | ||
| 地址 | Coralville IA US | ||