USE OF FSK IN PREVENTING AND TREATING CHRONIC OBSTRUCTIVE PULMONARY DISEASE

摘要

Provided in the invention is a novel use of the compound forskolin (FSK) in preventing and treating chronic obstructive pulmonary disease (COPD). The FSK can be independently used as an effective component for drug use or health-care use, and also can be prepared into tablets, buccal tablets, capsules, granules, oral solutions, injections, aerosols, emplastrum and the like with other components free from repulsive interactions. The present invention adopts administration methods such as FSK oral intragastric administration and intraperitoneal injections and the like, and experimental research has been performed on a cigarette smoke inhalation induction mouse COPD model and an elastase induction mouse COPD model to prove that FSK has an obvious preventative/treatment effect on the cigarette smoke inhalation induction COPD and the elastase induction COPD. Furthermore, the acute toxicity and long term toxicity tests of FSK prove that the present invention is safe, the dosage of an adult is 10-120 mg every day, and the administration methods comprise oral administration, injection and spraying.