FKBP52-Tau interaction as a novel therapeutical target for treating the neurological disorders involving tau dysfunction

摘要

The invention belongs to the fields of diagnostic, prognostic, and monitoring assays of neurological disorders involving Tau dysfunction. A direct interaction between proteins FKBP52 and Tau is reported. Herein are described methods for testing a subject thought to have or be predisposed to having a neurological disorder involving Tau dysfunction; and also for preventing or treating a neurological disorder involving Tau dysfunction in a subject in need thereof.

主权项

1. A method of testing a subject thought to have or be predisposed to having a neurological disorder involving Tau dysfunction, which comprises the steps of
I) analyzing a sample of interest obtained from said subject by:
measuring a level of a complex between a FKBP52 protein and a Tau protein by contacting the sample of interest with a binding partner capable of selectively interacting with the FKBP52 protein and another binding partner capable of selectively interacting with Tau protein present in the sample of interest; and II) concluding, based on results obtained in said analyzing step, whether or not said subject has or is predisposed to having a neurological disorder involving Tau dysfunction.