| 发明名称 | Methods for promoting reinnervation of auditory hair cells | ||
| 摘要 | This invention relates to methods for promoting reinnervation of auditory hair cells, specifically, by inhibiting Repulsive Guidance Molecule a (RGMa), a repulsive axonal guidance molecule that is expressed in the cochlea, or its receptor, neogenin. | ||
| 申请公布号 | US9125894(B2) | 申请公布日期 | 2015.09.08 |
| 申请号 | US201113877356 | 申请日期 | 2011.09.29 |
| 申请人 | Massachusetts Eye & Ear Infirmary | 发明人 | Edge Albert |
| 分类号 | A61K39/395;A61K31/7088;A61K31/7105;A61K45/06;A61K31/713;A61K35/30;C07K16/22 | 主分类号 | A61K39/395 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A method of promoting or enhancing auditory neuron innervation of auditory hair cells, the method comprising administering to the neurons an effective amount of an inhibitor of Repulsive Guidance Molecule a (RGMa), wherein the inhibitor is an inhibitory antibody or antigen-binding portion thereof that binds specifically to RGMa. | ||
| 地址 | Boston MA US | ||