| 发明名称 |
INHIBITION OF VIRAL GENE EXPRESSION |
| 摘要 |
<p>This invention relates to modified short interfering RNA (siRNA) nucleic acid molecules particularly siRNA s which have been modified by the addition of a 2 0 guanidinopropyl (GP) modified nucleoside. In particular the invention relates to modified siRNAs which are capable of silencing target sequences methods of treating and preventing infection by using the siRNAs medicaments containing the siRNAs and use of the siRNAs.</p> |
| 申请公布号 |
IN3921CHN2014(A) |
申请公布日期 |
2015.09.04 |
| 申请号 |
IN2014CH03921 |
申请日期 |
2014.05.23 |
| 申请人 |
UNIVERSITY OF THE WITWATERSRAND JOHANNESBURG;GOETHE UNIVERSITY |
发明人 |
ARBUTHNOT PATRICK;HEAN JUSTIN;ELY ABDULLAH;MARIMANI MUSA;BRZEZINSKA JOLANTA;DONOFRIO JENNIFER;BUFF MAXIMILIAN C. R.;ENGELS JOACHIM W.;BERNHARDT STEFAN |
| 分类号 |
C12N15/113;A61K31/712;A61P31/20 |
主分类号 |
C12N15/113 |
| 代理机构 |
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