发明名称 |
THERAPEUTIC AGENT FOR SOLID CANCER |
摘要 |
Disclosed is a novel means effective for the treatment of solid cancer, the prevention of metastasis of solid cancer and the prevention of recurrence of solid cancer in human bodies. A therapeutic agent for solid cancer according to the present invention contains, as an active ingredient, an anti-CD4 antibody having a high cytotoxic activity, an anti-CD4 antibody having a cytotoxic component bound thereto or an antigen-binding fragment of any one of the antibodies. Each of the anti-CD4 antibodies is a human-type chimeric antibody, a humanized antibody or a human antibody each against human CD4. The therapeutic agent according to the present invention can exhibit a superior effect when used in combination with an antagonist or agonist for an immune check point molecule, a low-molecular-weight anti-cancer agent or the like. The therapeutic agent is also effective for the prevention of the recurrence and metastasis of solid cancer. |
申请公布号 |
WO2015125652(A1) |
申请公布日期 |
2015.08.27 |
申请号 |
WO2015JP53569 |
申请日期 |
2015.02.09 |
申请人 |
IDAC THERANOSTICS, INC.;THE UNIVERSITY OF TOKYO |
发明人 |
ITO, SATORU;YOKOCHI, SHOJI;MATSUSHIMA, KOUJI;UEHA, SATOSHI;ISHIWATA, YOSHIRO |
分类号 |
A61K39/395;A61P35/00 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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