| 主权项 |
1. A method of treating a cancer patient in need of cancer treatment, wherein the method comprises the steps of:
identifying a patient in need of treatment, and having cancer associated with cancer tissue having androgen receptor (AR) positive target cells or target tissue and estrogen receptor (ER) negative target cells or target tissue; and administering to the patient in need of treatment an effective amount of a steroid compound specifically binding to the androgen receptor (AR) but not metabolized by aromatase, wherein the cancer is selected from the group consisting of breast cancer, endometrial carcinoma, cervix carcinoma, epithelial ovarian carcinoma, uterine carcinoma, endometrial carcinoma, cervix carcinoma, epithelial ovarian carcinoma, or uterine carcinoma, fibroadenoma, macromastia, mastopathy, and wherein the steroid compound is a compound of the formula:whereina, b and c respectively denote, independently from each other, a single bond or a double bond;R1 is hydrogen or C1 to C6 alkyl;R2 is OR5, wherein R5 is hydrogen or C1 to C6 straight chain or branched alkyl;R3 is, in case of c being a single bond, hydrogen or C1 to C6 alkyl, or in case of c being a double bond, CHR5, wherein R5 is the same as defined before;R4 is hydrogen, C1 to C6 alkyl, unsubstituted or C1 to C6 alkyl-substituted phenyl, COR6 acyl group; andR6 is hydrogen, C1 to C6 straight chain or branched alkyl, phenyl or benzoyl respectively unsubstituted or substituted by C1 to C6 alkyl; or pharmaceutically acceptable salts thereof. |
