Method of Detecting and Treating Tuberous Sclerosis Complex Associated Disorders

摘要

Disclosed are methods of detecting and treating tuberous sclerosis complex associated disorders. Also disclosed are methods of identifying agents for treating tuberous sclerosis complex associated disorders.

主权项

1. A method of diagnosing or determining the susceptibility to a tuberous sclerosis complex associated disorder in a subject, the method comprising: (a) providing from the subject a test cell population comprising cells capable of expressing one or more nucleic acid sequences selected from the group consisting of TSC 1-8, 10-12, 15-141 and 142; (b) measuring expression of one or more of the nucleic acid sequences in the test cell population; and (c) comparing the expression of the nucleic acid sequences in the test cell population to the expression of the nucleic acid sequences in a reference profile comprising at least one cell from a subject not suffering from a tuberous sclerosis complex associated disorder; and (d) identifying a difference in expression levels of the nucleic acid sequences, if present, in the test cell population and reference profile, thereby diagnosing or determining the susceptibility to a tuberous sclerosis complex associated disorder in the subject.