Satiation devices and methods

摘要

A device for inducing weight loss in a patient includes a tubular prosthesis self-expandable from a collapsed position in which the prosthesis has a first diameter to an expanded position in which the prosthesis has a second, larger, diameter. In a method for inducing weight loss, the prosthesis is placed in the collapsed position and inserted into a stomach of a patient. The prosthesis is allowed to self-expand from the collapsed position to the expanded position and into contact with the walls of the stomach, where it induces feelings of satiety and/or inhibits modulation of satiety-controlling factors such as Ghrelin.

主权项

1. A device for implantation in a patient having an esophagus, a gastro-esophageal junction, a stomach, and an intestine, comprising:
a gastro-esophageal junction prosthesis extending from an upstream opening at an upstream end to a downstream opening at a downstream end, wherein the upstream end is configured to be attached within the gastro-esophageal junction; a gastric bypass sleeve including an intestinal portion, the sleeve extending from a proximal opening to a distal opening, the sleeve being fluidly coupled to the prosthesis and dimensioned to be positioned such that the proximal opening is positioned proximate the gastro-esophageal junction and the intestinal portion is positioned in the intestine, and one or more attachment elements configured to attach the prosthesis to the gastro-esophageal junction, wherein the downstream opening of the prosthesis is coupled to the proximal opening of the sleeve, and wherein the upstream opening of the prosthesis is configured to be positioned in alignment with the esophagus.