LYOPHILIZED VIRAL FORMULATIONS

摘要

Provided herein are lyophilized viral formulations useful for the stabilization and storage of viruses and methods of preparing these formulations. The lyophilized viral formulations described herein include a virus (e.g., a purified virus) and a non-viral composition including excipients. The formulations can be used, for example, to retain the infectivity or immunogenicity of viruses during periods of storage.

主权项

1. A viral formulation, comprising:
(a) a purified virus; and (b) a non-viral composition comprising:
(i) sucrose;(ii) Mg2+; and(iii) a non-ionic surfactant, wherein the viral formulation is lyophilized; wherein the non-viral composition, prior to lyophilization, is a liquid non-viral composition further comprising a liquid carrier; wherein the concentration of sucrose in the liquid non-viral composition, prior to lyophilization, is less than 5% based on the weight of the liquid non-viral composition; wherein the liquid non-viral composition, excluding the liquid carrier, is substantially free of monovalent cationic salts, non-sucrose polyols, and carboxylates; and wherein the non-viral composition is provided in an amount effective to stabilize the purified virus.