COMBINATIONS OF IKKi/TBK1 INHIBITORS WITH BETA ADRENERGIC AGONISTS OR SYMPATHETIC NERVOUS SYSTEM ACTIVATORS

摘要

Provided herein are methods of treating obesity and obesity-related conditions comprising the administration of combinations of IKKε/TBK1 inhibitors with beta adrenergic agonists or sympathetic nervous system activators, and pharmaceutical compositions comprising such combinations.

主权项

1. A method of treating a subject having a condition associated with obesity, insulin resistance, or hepatic steatosis, comprising: administering to a subject having a condition or symptoms associated with obesity, insulin resistance, or hepatic steatosis: (i) an IKKε and/or TBK1 inhibitor, and (ii) a beta adrenergic agonist or sympathetic nervous system activator, such that said condition or symptoms are reduced or eliminated.