| 主权项 |
1. Compounds of the formula I in which R denotes H, OH, A or NR4R4′, R1 denotes Ar1, Het1, CN, A or —C≡C—Ar1, R2 denotes Het2, NR3Cyc, NR3CR3CON(R3)2, NR3[C(R3)2]pCR3(NH2)CH2OA or NR3[C(R3)2]pN(R3)2, Ar1 denotes phenyl, which is mono-, di- or trisubstituted by A, (CH2)nHet3, [C(R3)2]nOR3, [C(R3)2]nN(R3)2, NO2, CN, Hal, COOR3, CON(R3)2, NR3COA, NR3SO2A, SO2N(R3)2 and/or S(O)mA, Het1 denotes 3,6-dihydro-2H-pyranyl, tetrahydropyridinyl, 1,3-dihydro-benzimidazolyl, pyrazolyl, chromanyl, 1,2,3,4-tetrahydro-pyrazolo[1,5-a]pyridinyl, 6,7-dihydro-4H-pyrazolo[5,1-c][1,4]-oxazinyl, 1,4-dihydro-benzo[d][1,3]oxazinyl, 4H-benzo[1,4]oxazinyl, benzimidazolyl, pyridyl, pyrimidinyl, imidazolyl, pyrazolyl, furyl, thiazolyl, triazolyl, benzotriazolyl, indolyl, indazolyl, 1,3- or 2,3-dihydro-indolyl, each of which is unsubstituted or mono-, di-, tri- or tetrasubstituted by A, CN, OH, OA, Hal, SO2NH2, (CH2)nNH2, (CH2)nNHA, (CH2)nNA2 and/or ═O, Het2 denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, tetrahydropyranyl, pyrazolyl, indazolyl, azetidinyl or octahydro-benzimidazolyl, each of which is mono-, di- or trisubstituted by Hal, A, (CH2)nNH2, (CH2)nNHA, (CH2)nNA2, (CH2)nOH and/or (CH2)nOA, Het3 denotes piperidinyl, piperazinyl, pyrrolidinyl, morpholinyl, imidazolidinyl, pyridyl, pyrimidinyl, imidazolyl, pyrazolyl, furyl, thiazolyl or triazolyl, each of which is unsubstituted or mono- or disubstituted by A and/or ═O, R3 denotes H or alkyl having 1, 2, 3 or 4 C-atoms, R4, R4′ each, independently of one another, denote H or A, A denotes unbranched or branched alkyl having 1-10 C atoms, in which 1-7H atoms may be replaced by F and/or in which one or two non-adjacent CH2 groups may be replaced by 0 and/or NH,
orcyclic alkyl having 3-7 C atoms, Cyc denotes cyclic alkyl having 3-7 C atoms, which may be unsubstituted or monosubstituted by NH2, CN, CONH2 or OH, m denotes 0, 1 or 2, n denotes 0, 1, 2, 3 or 4, P denotes 1, 2, 3 or 4,
and pharmaceutically acceptable solvates, salts, enantiomers, tautomers and stereoisomers thereof, including mixtures thereof in all ratios. |
