G-PROTEIN COUPLED RECEPTORS IN HEDGEHOG SIGNALING

摘要

The disclosure provides methods for identifying TPRA40 antagonists and agonists. The method further provides methods for inhibiting hedgehog signaling and/or inhibiting unwanted cell proliferation, such as unwanted cell proliferation caused, in whole or in part, by hyperactive hedgehog signaling, using a TPRA40 antagonist.