发明名称 Oligome-bis-chromonyl compound conjugates
摘要 The invention provides oligomer-bis-chromonyl compound conjugates. The conjugates of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered compounds.
申请公布号 US9095621(B2) 申请公布日期 2015.08.04
申请号 US200912989074 申请日期 2009.04.23
申请人 NEKTAR THERAPEUTICS 发明人 Riggs-Sauthier Jennifer;Deng Bo-Liang
分类号 C07D311/00;A61K31/35;A61K47/48 主分类号 C07D311/00
代理机构 代理人
主权项 1. A compound having the following structure:wherein: R1 is selected from the group consisting of hydrogen, hydroxy, halo, lower alkyl, and lower alkoxy; R2 is selected from the group consisting of hydrogen, hydroxy, halo, lower alkyl, and lower alkoxy; R3 is selected from the group consisting of hydrogen, hydroxy, halo, lower alkyl, and lower alkoxy; R4 is selected from the group consisting of hydrogen, hydroxy, halo, lower alkyl, and lower alkoxy; R5 is selected from the group consisting of hydrogen, hydroxy, halo, lower alkyl, and lower alkoxy; R6 is selected from the group consisting of hydrogen, hydroxy, halo, lower alkyl, and lower alkoxy; L is selected from —CH2—CH═CH—CH2—,  —CH2—CH(OH)—CH2—, —CH2—CH(OH)—CH2—O—CH2—CH(OH)—CH2—, —CH2—O—CH2—, —CH2—CH2—CH(CH3)—CH2—CH2—, —CH2—CO—CH2—and —CH2—CH2—O—CH2—CH2—; (a) is one; (b) is one; X1, when present, is a spacer moiety selected from the group consisting of —C(O)O—, —OC(O)—, —NH—C(O)O—, —OC(O)—NH— and a carbonyl; X2, when present, is a spacer moiety selected from the group consisting of —C(O)O—, —OC(O)—, —NH—C(O)O—, —OC(O)—NH— and a carbonyl; POLY1 is a poly(ethylene oxide) oligomer having a number of repeating monomers in the range of from 1 to 30; and POLY2 is a poly(ethylene oxide) oligomer having a number of repeating monomers in the range of from 1 to 30.
地址 San Francisco CA US