| 主权项 |
1. A production method of a pharmaceutical product, comprising:
providing pharmaceutically inert elliptical core particles having a minor axis/major axis ratio of 0.7 or greater; and spraying a layering liquid on the core particles, thereby coating the core particles with a drug-containing layer, wherein the layering liquid comprises:
(1) from 0.01 to 50% by mass of hardly water-soluble drug particles having a maximum major axis of not greater than 30% of an average minor axis of the core particles and a maximum minor axis of not greater than 12% of the average minor axis of the core particles;(2) from 0.1 to 2% by mass of a micronized microcrystalline cellulose; and(3) from 0.01 to 1% by mass of an emulsifier, wherein the hardly water-soluble drug is any one selected from the group consisting of amcinonide, ibuprofen, indomethacin, ethenzamide, cefotiam hexetil hydrochloride, nicardipine hydrochloride, omeprazole, prednisolone valerate acetate, diflucortolone valerate, dexamethasone valerate, betamethasone valerate, clarithromycin, griseofulvin, clonazepam, chloramphenicol, synthetic peptide compounds, cortisone acetate, diflorasone diacetate, dexamethasone acetate, triamcinolone acetate, paramethasone acetate, hydrocortisone acetate, fludrocortisone acetate, methylprednisolone acetate, diazepam, digitoxin, digoxin, difluprednate, beclometasone dipropionate, betamethasone dipropionate, sulpiride, sulfathiazole, cefuroxime axetil, dexamethasone, triamcinolone, triamcinolone acetonide, nicardipine, nifedipine, nilvadipine, noscapine, halcinonide, hydrocortisone, flumetasone pivalate, phenacetin, phenitoin, budesonide, prazepam, fluocinonide, fluocinolone acetonide, fluorometholone, fludroxycortide, prednisolone, alclometasone dipropionate, clobetasol propionate, dexamethasone propionate, deprodone propionate, betamethasone, migrenin, methylprednisolone, ubidecarenone, clobetasone butyrate, hydrocortisone butyrate, hydrocortisone butyrate propionate, riboflavin butyrate, lansoprazole, and riboflavin. |
