| 发明名称 | Series of skin whitening (lightening) compounds | ||
| 摘要 | The present invention is directed to inhibitors of tyrosinase, pharmaceutical compositions comprising such tyrosinase inhibitors, and methods of making and using the same. Specifically, included in the present invention are compositions of matter comprised of at least one 2,4-dihydroxybenzene analog, which inhibit the activity of tyrosinase and which inhibit the overproduction of melanin. | ||
| 申请公布号 | US9096507(B2) | 申请公布日期 | 2015.08.04 |
| 申请号 | US201414154013 | 申请日期 | 2014.01.13 |
| 申请人 | Unigen, Inc. | 发明人 | Nandy Sandip K.;Liu Jiyun;Nesterov Alexandre Mikhailovitch;Hertel Carmen;Padmapriya Abeysinghe A. |
| 分类号 | C07C43/295;C07D263/57;A61K31/09;C07D213/64;A61K31/341;A61Q19/08;A61K31/357;A61K8/34;A61K31/4406;C07D307/12;C07C45/67;C07C43/23;C07D213/30;A61K8/49;C07C45/74;A23L3/3481;A23B7/154;A61Q19/02;C07C39/11;C07C39/15;C07C49/83;C07D307/42;C07D317/54 | 主分类号 | C07C43/295 |
| 代理机构 | Seed IP Law Group, PLLC | 代理人 | Seed IP Law Group, PLLC |
| 主权项 | 1. A compound having the following structure (II):or a pharmaceutically acceptable salt thereof, wherein: X is H, or OH; and R is optionally substituted: biphenyl, pyridin-2-yl, pyridin-3-yl, pyridin-4-yl or furan-3-yl; R is substituted furan-2-yl; or R is 2,4,6-trimethoxyphen-1-yl. | ||
| 地址 | Seattle WA US | ||