发明名称 |
Recombinant probiotic bacteria for the prevention and treatment of inflammatory bowel disease (IBD) and irritable bowel syndrome (IBD) |
摘要 |
The present invention relates to the general field of therapy of Inflammatory Bowel Disease (IBD) and/or Irritable Bowel Syndrome (IBS). Thus, the invention relates to a molecule selected from the trappin-2 protein or an active fraction of the trappin-2 protein, a member of the WAP family proteins or an active fraction of a member of the WAP family proteins or a member of the Serpin family proteins or an active fraction of a member of the Serpin family proteins for the treatment of Irritable Bowel Syndrome (IBS). The invention also relates to a recombinant food-grade bacterium comprising a gene selected from a gene coding for the trappin-2 protein or an active fraction of the trappin-2 protein, a gene coding for a member of the WAP family proteins or an active fraction of a member of the WAP family proteins, or a gene coding for a member of the serpin family proteins or an active fraction of a member of the serpin family proteins. |
申请公布号 |
AU2011206532(B2) |
申请公布日期 |
2015.07.30 |
申请号 |
AU20110206532 |
申请日期 |
2011.01.14 |
申请人 |
INSTITUT PASTEUR;INSTITUT NATIONAL DE LA RECHERCHE AGRONOMIQUE (INRA);UNIVERSITE PARIS DIDEROT - PARIS 7;INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) |
发明人 |
VERGNOLLE, NATHALIE;SALLENAVE, JEAN-MICHEL;LANGELLA, PHILIPPE;BERMUDEZ-HUMARAN, LUIS |
分类号 |
C07K14/81;A61K35/74;C12N15/74;C12R1/225 |
主分类号 |
C07K14/81 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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