METHOD FOR PRODUCING ANTI-AMYLOID BETA ANTIBODY

摘要

PROBLEM TO BE SOLVED: To provide and develop an improved system for producing proteins or polypeptides by cell culture in a culture medium.SOLUTION: Provided is an improved system for a large scale production of protein and/or polypeptide characterized by cell culture, particularly characterized by one or more of the following (i) to (v): (i) the cumulative amount of amino acids per unit volume is more than about 70 mM; (ii) the molar ratio of cumulative amount of glutamine to cumulative amount of asparagine is less than about 0.2; (iii) the molar ratio of cumulative amount of glutamine to cumulative amount of total amino acids is less than about 0.2; (iv) the molar ratio of cumulative amount of inorganic ions to cumulative amount of total amino acids is about 0.4-1; and (v) the combined cumulative amount of glutamine and asparagine per unit volume is more than about 16 mM.