METHOD AND SYSTEM FOR BIOINFORMATICS ANALYSIS OF HPV PRECISE TYPING HPV

摘要

A method and system for bioinformatics analysis of HPV precise typing is disclosed in the invention, said method comprises: receiving sequencing fragments obtained through high-throughput sequencing technique; comparing a sample linker sequence in sequencing fragments with a sample linker sequence library to implement separation of samples; comparing the sequencing fragments with reference genomic sequence, filtering the sequence that has been compared; determining HPV type of the filtered sequence fragments or determining them to be negative; combining the sequence fragments whose types have been determined sample by sample; performing filtering according to quantity and ratio of the combined sequence fragments which support corresponding type; identifying HPV type of every sample or identifying them to be negative finally. The method and system for bioinformatics analysis of HPV precise typing provided in the invention utilizes bioinformatics analysis method and technical solution to implement rapid detection of large samples and rapid detection of infected HPV type with relative high sensitivity and specificity.