Carriers having biological substance

摘要

The present invention relates to biological substance-immobilized fibers wherein a biological substance is immobilized on a fiber, fibers retaining a biological substance-immobilized gel, and fiber alignments having bundles of the above-described fibers and slices of the same.

主权项

1. A method for producing a fiber alignment slice having coordinates for each fiber unit thereof, comprising:
(aa) longitudinally binding together a plurality of fibers, each of which has had one type of biological substance immobilized to it to form a fiber alignment; (a) sequentially cutting the fiber alignment to obtain a series of m fiber alignment slices S(1), S(2), . . . S(h), . . . S(m); (b) selecting any given slice S(h) from m number of slices and determining two-dimensional coordinates for each fiber unit contained in slice S(h) from coordinate reference points provided on slice S(h); (c) determining the two-dimensional coordinates of each fiber unit contained in another slice of the same fiber alignment S(i) based on the two dimensional coordinates determined for slice S(h) in step (b) and the coordinate reference points in said slice S(i) and recording said coordinates on a computer readable medium, wherein slice S(i) is close enough to slice S(h) to permit interpolation of the coordinates of any intervening slices from the coordinates determined for S(h) and S(i); and (d) repeating steps (b) and (c) to determine the two-dimensional coordinates of each fiber unit in other members of the series of fiber alignment slices;
wherein the fiber alignment of (aa) when sequentially sliced produces a fiber alignment slice on which the one type of biological substance immobilized in or on each fiber of the fiber alignment slice is accessible to binding by a ligand for that biological substance;wherein said one type of biological substance is immobilized inside of or on a porous fiber prior to longitudinally binding the fibers together.