发明名称 |
SOLID FORMS OF (R)-1-(2,2-DIFLUOROBENZO[D][1,3]DIOXOL-5-YL)-N-(1-(2,3-DIHYDROXYPROPYL)-6-FLUORO-2-(1-HYDROXY-2-METHYLPROPAN-2-YL)-1H-INDOL-5-YL)CYCLOPROPANECARBOXAMIDE |
摘要 |
PROBLEM TO BE SOLVED: To provide stable solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide that can be used readily in pharmaceutical compositions suitable for use as therapeutics.SOLUTION: The present invention relates to solid forms of (R)-1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide (Compound 1) in a substantially crystalline form (Form A) or amorphous form, pharmaceutical compositions thereof, and methods of treatment therewith. |
申请公布号 |
JP2015127334(A) |
申请公布日期 |
2015.07.09 |
申请号 |
JP20150046120 |
申请日期 |
2015.03.09 |
申请人 |
VERTEX PHARMACEUTICALS INC |
发明人 |
ALI KESHAVARZ-SHOKRI;ZHANG BEILI;TIM EDWARD ALCACIO;ELAINE CHUNGMIN LEE;YUEGANG ZHANG;MARIUSZ KRAWIEC |
分类号 |
C07D405/12;A61K9/14;A61K31/404;A61K45/00;A61K47/20;A61K47/38;A61P1/10;A61P1/16;A61P1/18;A61P3/00;A61P3/06;A61P3/10;A61P5/10;A61P5/14;A61P7/00;A61P7/04;A61P7/10;A61P11/00;A61P11/02;A61P11/06;A61P13/02;A61P13/12;A61P15/08;A61P19/00;A61P19/08;A61P19/10;A61P21/00;A61P21/04;A61P25/00;A61P25/08;A61P25/14;A61P25/16;A61P25/28;A61P27/02;A61P35/00;A61P37/06;A61P37/08;A61P43/00 |
主分类号 |
C07D405/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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