Vitamin D₃lactone derivatives

摘要

A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof;;
[wherein R1 refers to hydrogen atom, C1-C6 alkyl group optionally substituted with hydrogen group or C1-C6 alkoxy group optionally substituted with hydroxyl group, R2a and R2b refer to hydrogen atom, C1-C10 alkyl group optionally substituted with hydroxyl group, C6-C10 aryl group optionally substituted with hydroxyl group or C7-C12 aralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which R1 is a hydrogen atom or a methyl group and R2a and R2b are hydrogen atoms is excluded].

主权项

1. A compound represented by the following Formula (1):wherein R1 is a methyl group, a 3-hydroxypropyl group, or a 3-hydroxypropoxy group and a combination of R2a and R2b is hydrogen atom and methyl group, hydrogen atom and ethyl group, hydrogen atom and propyl group, hydrogen atom and butyl group, hydrogen atom and isobutyl group, both hydrogen atoms or both methyl groups, or alternatively R2a and R2b may be combined together to form a cyclopropane ring together with the carbon atom to which they are bonded; with the proviso that a compound in which R1 is methyl group and R2a and R2b are hydrogen atoms is excluded, and
wherein the steric configuration of the 1-position of the above Formula (1) is α configuration and that of the 3-position is β configuration.