Fluorescent emulsions for optical imaging

摘要

The invention relates to a fluorescent emulsion, to a diagnostic reagent containing the same, and to the use thereof in the preparation of a diagnostic reagent for in vivo fluorescence imaging.

主权项

1. A metastable fluorescent emulsion of oil-in-water type that is stable at pH 7.3, comprising
at least one aqueous continuous phase and at least one oily dispersed phase; wherein the dispersed phase comprises droplets of:
at least one liquid biocompatible oil composed of at least one plant or animal oil andat least one crystallizable oil having the following composition:
C8: 0.1 to 0.9%,C10: 0.1 to 0.9%,C12: 25 to 50%,C14: 10 to 24.9%,C16: 10 to 24.9%,C18: 10 to 24.9%, wherein said droplets have an average diameter greater than or equal to 10 nm and less than or equal to 200 nm and contain at least one lipophilic fluorophore which absorbs and emits at a wavelength between 640 and 900 nm, and wherein said droplets are stabilized by a surfactant layer located at the periphery of said droplets, wherein said layer comprises, as a mixture, at least one amphiphilic surfactant and at least one stealth cosurfactant.