Compounds and methods for purifying peptides produced by solid phase peptide synthesis

摘要

The invention relates to compounds which can be used for purifying peptides produced by solid phase peptide synthesis. In addition, the invention relates to methods for purifying peptides produced by solid phase peptide synthesis using the compounds according to the invention.

主权项

1. A compound having general formula (I):
X1-L-X2  (I) wherein:
X1 is selected from the group consisting of —N3 or —C≡CH,L represents a linker separating X1 and X2,X2 is selected from the group consisting of the compounds having general formula (A), and the compounds having general formula (C): wherein:
Y1 and Y2 independently represent —CH— or —N—,Y3 represents —OH or a leaving group,R1 and R2 independently represent —H, —CH3, or a C2-C5 alkyl,the dotted line to R3 represents an optional double bond wherein,when the double bond is present, R3 is O and R4 is absent,when the double bond is not present, R3 and R4 represent —CH3; and wherein the compounds of general formula (C) are: wherein X5 is a leaving group.