Nanostructural materials that increase mineralization in bone cells and affect gene expression through miRNA regulation and applications of same

摘要

A method of inducing mineralization in a bone cell is described. The method comprises contacting a bone cell with a composition comprising nanoparticles. The nanoparticles can be single-walled carbon nanotubes, hydroxyapatite nanoparticles, TiO2 nanoparticles or silver nanoparticles. The bone cell can be an osteoblast cell. A method for increasing bone mass, bone healing or bone formation is also described which comprises administering to a subject in need thereof an effective amount of a composition comprising nanoparticles. The subject can suffer from a bone disease such as osteoporosis. The subject can suffer from a bone fracture and the method can comprise contacting bone cells near the bone fracture site with the composition. The composition can further comprise a pharmaceutically acceptable carrier.

主权项

1. A method comprising:
contacting a bone cell with loose nanoparticles; wherein the loose nanoparticles are internalized into the bone cell and induce mineralization in the bone cell wherein the loose nanoparticles are selected from the group consisting of silver nanoparticles, TiO2 nanoparticles, hydroxyapatite nanoparticles, single-walled carbon nanotubes and combinations thereof.