LIPID MEMBRANE STRUCTURE HAVING INTRANUCLEAR LOCALIZATION PROPERTY

摘要

A lipid membrane structure for delivering a substance into the nucleus of a cell. The lipid membrane structure can deliver a nucleic acid into the nucleus of an immunocyte such as a dendritic cell with high efficiency. In the lipid membrane structure, a lipid membrane is modified with (a) a polypeptide which comprises the amino acid sequence represented by SEQ ID NO: 1 and/or (b) a polypeptide which comprises an amino acid sequence produced by the deletion and/or substitution and/or insertion of one or several amino acid residues in the amino acid sequence represented by SEQ ID NO: 1 and which has an activity of promoting the migration of the lipid membrane structure into the nucleus of a cell.