发明名称 |
Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glutamyl-prolyl-tRNA synthetases |
摘要 |
Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. |
申请公布号 |
US9062301(B2) |
申请公布日期 |
2015.06.23 |
申请号 |
US201113696048 |
申请日期 |
2011.05.04 |
申请人 |
aTyr Pharma, Inc.;Pangu BioPharma Limited |
发明人 |
Greene Leslie Ann;Chiang Kyle P.;Hong Fei;Vasserot Alain Philippe;Watkins Jeffry D.;Quinn Cheryl L.;Lo Wing-Sze;Mendlein John D. |
分类号 |
A61K38/53;A61K47/48;C07K16/40;C12N9/00 |
主分类号 |
A61K38/53 |
代理机构 |
Cooley LLP |
代理人 |
Cooley LLP |
主权项 |
1. A therapeutic composition, comprising an isolated glutamyl-prolyl-tRNA synthetase (Glu-ProRS) polypeptide of about 200 to about 750 amino acids in length and comprising an amino acid sequence that is at least 95% identical to SEQ ID NO:175, wherein the polypeptide has an extracellular signaling activity and a solubility of at least about 5 mg/mL, and wherein the composition has a purity of at least about 95% on a protein basis and less than about 10 EU endotoxin/mg protein. |
地址 |
San Diego CA US |