发明名称 Pyrido [3,4-C] [1,9] phenanthroline and 11, 12 dihydropyrido [3,4-C] [1,9] phenanthroline derivatives and the use thereof, particularly for treating cancer
摘要 New phenanthroline derivatives as drug as well as methods for producing said compounds are provided.
申请公布号 US9062054(B2) 申请公布日期 2015.06.23
申请号 US201314390661 申请日期 2013.04.05
申请人 CHRISTIAN-ALBRECHTS-UNIVERSITAET ZU KIEL 发明人 Clement Bernd;Meier Christopher;Heber Dieter;Stenzel Lars
分类号 C07D471/14;A61K31/4745;A61P29/00;A61P31/00;A61P31/04;A61P31/10;A61P31/12;A61P33/00;A61P35/00 主分类号 C07D471/14
代理机构 Clark & Elbing LLP 代理人 Clark & Elbing LLP ;Bicker-Brady Kristina
主权项 1. A compound (i) of general formula I or IIwherein R1 is equal to a phenyl ring of the formulaRX is selected from Cl, Br or I, and each RY is, independently, selected from H, OH, OMe, OEt or halogen; or (ii) a compound of the general formula III or IV,wherein R1 is either equal to a phenyl ring of the formulawhich carries at least one substituent RY in the meta position, wherein each RY is, independently, selected from H, OH, OMe, OEt, halogen, or is equal to a five-membered aromatic heterocycle of the formulawhereinW is selected from O, S, or NH;Z is selected from H, F, Cl, Br, I, NHX, OX, and SX;X is selected from H, dimethylaminoalkyl, diethylaminoalkyl ω-(1,3-diazol-1-yl)-alkyl, hydroxyalkyl, alkoxyalkyl, thiolalkyl, alkylthioalkyl group, wherein alkyl is equal to methyl, ethyl or propyl; andA is equal to O or S,and pharmaceutically acceptable salts, solvates and prodrugs thereof.
地址 Kiel DE