BILAYER TABLET FORMULATIONS

摘要

PROBLEM TO BE SOLVED: To provide a method for producing bilayer tablet formulations, and to provide a therapeutic method of diseases or disorders associated with a sodium dependent glucose transporter inhibitor (SGLT2) activity using the bilayer tablet formulations.SOLUTION: The invention provides a bilayer tablet formulation which contains (1) a first layer which is metformin sustained release formulation and (2) a second layer which is SGLT2 inhibitor formulation, and may contain (3) a film coating which coats the first layer and the second layer suitably. Further in the bilayer tablet formulation, the SGLT2 inhibitor is Canagliflozin, Dapagliflozin, Dapagliflozin (S) propylene glycol hydroxide, or Dapagliflozin (R) propylene glycol hydroxide.