PHARMACEUTICAL FORMULATIONS FOR CARRIER-MEDIATED TRANSPORT STATINS AND USES THEREOF

摘要

The present invention relates to formulations comprising therapeutically effective amounts of at least one acid-stable, carrier-mediated transport statin, at least one poorly water-soluble, carrier-mediated transport statin, or at least one large molecular weight, carrier-mediated transport statin, such as atorvastatin and rosuvastatin, or a pharmaceutically acceptable salt thereof, and methods of their use. The present formulations and methods are designed to exhibit a controlled-release of a therapeutic amount of the statin in the small intestine, thereby limiting systemic exposure of the statin and maximizing liver-specific absorption of the drug. The formulations and methods of the present invention are particularly useful for treating and/or preventing conditions that are benefited by decreasing levels of lipids and/or cholesterol in the body.

主权项

1. A method of increasing the hepatic bioavailability of at least one acid-stable, carrier-mediated transport statin, comprising administering to a subject a therapeutically effective amount of the at least one acid-stable, carrier-mediated transport statin, or a pharmaceutically acceptable salt thereof, in a pharmaceutical formulation, wherein the formulation releases the statin at a rate that avoids saturating the intestinal and hepatocytic absorption mechanisms.