| 发明名称 | Process for the preparation of tenofovir | ||
| 摘要 | The present invention provides a process for preparation of tenofovir by dealkylation of its phosphonate ester using Ionic complexes. The present invention also provides a process for preparation of tenofovir disoproxil or a salt thereof using the tenofovir of the present invention. | ||
| 申请公布号 | US9056882(B2) | 申请公布日期 | 2015.06.16 |
| 申请号 | US201214356609 | 申请日期 | 2012.11.15 |
| 申请人 | Laurus Labs Private Ltd. | 发明人 | Indukuri Venkata Sunil Kumar;Joga Sree Rambabu;Gorantla Seeta Ramanjaneyulu;Chava Satyanarayana |
| 分类号 | A61K31/675;C07F9/6561 | 主分类号 | A61K31/675 |
| 代理机构 | Blank Rome LLP | 代理人 | Blank Rome LLP |
| 主权项 | 1. A process for preparation of tenofovir comprising the step of dealkylating (R)-9-[2-(di-Alk-phosphonomethoxy)propyl]adenine of Formulawherein Alk is independently a C1-4 alkyl, with a dealkylating ionic complex selected from the group consisting of a complex of amide and an acid, a complex of aluminum salt and an amide-acid reagent, and a complex of aluminum salt and an amine. | ||
| 地址 | Hyderabad IN | ||