| 发明名称 |
METHOD FOR PRODUCING RETINAL PIGMENT EPITHELIAL CELLS |
| 摘要 |
The invention relates to a method for producing retinal pigment epithelial cells. |
| 申请公布号 |
US2015159134(A1) |
申请公布日期 |
2015.06.11 |
| 申请号 |
US201414566184 |
申请日期 |
2014.12.10 |
| 申请人 |
PFIZER LIMITED |
发明人 |
CHOUDHARY PARUL;SURMACZ-CORDLE BEATA;FOX HEATHER DAWN ELLEN;WHITING PAUL JOHN |
| 分类号 |
C12N5/079;A61K35/30 |
主分类号 |
C12N5/079 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for producing retinal pigment epithelial (RPE) cells comprising the steps of:
(a) culturing pluripotent cells in the presence of a first SMAD inhibitor and a second SMAD inhibitor; (b) culturing the cells of step (a) in the presence of a BMP pathway activator and in the absence of the first and second SMAD inhibitors; and, (c) replating the cells of step (b). |
| 地址 |
SANDWICH GB |
