| 发明名称 | Use of human cells of myeloid leukaemia origin for expression of antibodies | ||
| 摘要 | The invention relates to a method for producing a protein molecule composition having a defined glycosylation pattern, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding at least a part of said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition. | ||
| 申请公布号 | US9051356(B2) | 申请公布日期 | 2015.06.09 |
| 申请号 | US200712440562 | 申请日期 | 2007.09.10 |
| 申请人 | Glycotope GmbH | 发明人 | Goletz Steffen;Danielczyk Antje;Baumeister Hans;Stahn Renate;Löffler Anja;Stöckl Lars |
| 分类号 | C07K14/00;C07K14/59;C07K16/00;C12P21/00;C12N5/078;C07K16/28;C07K16/30 | 主分类号 | C07K14/00 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Sloper, Esq. Jill Gorny |
| 主权项 | 1. A method for producing a protein molecule composition, comprising (a) introducing in a host cell which is an immortalized human blood cell at least one nucleic acid encoding said protein; and (b) culturing said host cell under conditions which permit the production of said protein molecule composition; and (c) isolating said protein molecule composition; wherein the host cell is selected from the group consisting of GT-2×[DSM ACC 2858], NM-H9D8 [DSM ACC 2806], NM-H9D8-E6 [DSM ACC 2807], and NM H9D8-E6Q 12 [DSM ACC 2856]. | ||
| 地址 | Berlin DE | ||