发明名称 |
Hydrogel and biomedical applications thereof |
摘要 |
The invention relates to a method for preparing a cross-linked sterile and homogeneous hydrogel for injection, characterized in that it comprises the following steps: (a) preparing an aqueous solution containing a polymer derived from cellulose and at least one water-soluble polymer, the total polymer content ranging from 0.5 and 5 wt %, preferably from 1 to 4 wt % and more preferably from 1.5 to 3 wt %; (b) optionally adding sold particles; (c) pouring the resulting liquid mixture with the optional solid particles into a vessel and closing dais vessel using a water-tight and gas-tight system; and (d) exposing said vessel containing the liquid and the optional solid particles to a radiation dose of between 5 and 50 kGy, preferably between 20 and 30 kGy, and more preferably of about 25 kGy. The invention also relates to a hydrogel obtained according to the above method and to the use thereof in medical applications. |
申请公布号 |
US9050392(B2) |
申请公布日期 |
2015.06.09 |
申请号 |
US200712515059 |
申请日期 |
2007.11.16 |
申请人 |
Biomatlante |
发明人 |
Bourges Xavier;Baroth Serge |
分类号 |
A61L27/52;A61K9/00;A61K41/00;A61L27/26;A61L27/48;A61L27/50;C08B15/00;C08B37/00;C08B37/08;C08J3/075;C08J3/28;C08L1/26;C08L5/08 |
主分类号 |
A61L27/52 |
代理机构 |
Pepper Hamilton LLP |
代理人 |
Pepper Hamilton LLP |
主权项 |
1. A method for preparing an injectable crosslinked sterile homogenous hydrogel, wherein it comprises the following successive steps:
(a) preparing an aqueous solution comprising a water-soluble polymer derived from cellulose and at least one second water-soluble polymer, wherein the total polymer concentration by weight is between 1% and 4% of the total weight; (b) adding bone substitute comprising solid particles; (c) pouring the resulting liquid mixture containing the solid particles, in a container, and closing said container by means of a system impervious to water and to gas; and (d) exposing the container containing the liquid and the optional solid particles to a dose of β or γ radiations comprised between 5 and 50 kGy, thus producing an injectable crosslinked sterile homogenous hydrogel; wherein the cellulose-derived polymersecond water-soluble polymer weight ratio is between 65/35 and 85/15. |
地址 |
Vigneux de Bretagne FR |