MARKERS OF THE MALE UROGENITAL TRACT

摘要

Methods for detecting urogenital conditions or urogenital status in a subject are described comprising measuring urogenital markers or polynucleotides, encoding the markers in a sample from the subject. The invention also provides localization or imaging methods for urogenital conditions, and kits for carrying out the methods of the invention. The invention also contemplates therapeutic applications for urogenital conditions employing urogenital markers, polynucleotides encoding the markers, and/or binding agents for the markers.

主权项

1. A method for diagnosis of a urogenital condition in a subject comprising:
(a) contacting a sample of seminal plasma from the subject with an antibody capable of detecting a urogenital marker TEX101 in the sample using an enzyme linked immunosorbent assay (ELISA); and (b) diagnosing the urogenital condition by detecting a change in the amount or status of the urogenital marker as compared to the amount or status of the same urogenital marker obtained from a control subject who does not suffer from the urogenital condition or a post-vasectomy subject, wherein the urogenital condition is non-obstructive azoospermia (NOA) or obstructive azoospermia (OA).