Cerberus/Coco derivatives and uses thereof

摘要

The invention relates to Cerberus/Dan/Gremlin polypeptides or variants thereof for use in treating a variety of disorders associated with myostatin, nodal and GDF-11. Preferred polypeptides are Coco or Cerberus derivatives.

主权项

1. A method for inhibiting myostatin signal transduction in an animal, comprising: administering to an animal in need thereof a pharmaceutical preparation comprising an effective amount of a myostatin antagonist that is a fusion protein comprising the myostatin binding domain of Coco and an immunoglobulin Fc domain, wherein the myostatin binding domain of Coco comprises the amino acid sequence of SEQ ID NO: 15 or a variant thereof, and wherein said pharmaceutical preparation is substantially free of pyrogenic materials so as to be suitable for injection as a human or veterinary therapeutic.