Pharmaceutical formulation containing gelling agent

摘要

Disclosed in certain embodiments is a controlled release oral dosage form comprising a therapeutically effective amount of a drug susceptible to abuse together with one or more pharmaceutically acceptable excipients; the dosage form further including a gelling agent in an effective amount to impart a viscosity unsuitable for administration selected from the group consisting of parenteral and nasal administration to a solubilized mixture formed when the dosage form is crushed and mixed with from about 0.5 to about 10 ml of an aqueous liquid; the dosage form providing a therapeutic effect for at least about 12 hours when orally administered to a human patient.

主权项

1. An immediate release oral dosage form comprising:
a mixture of (i) a therapeutically effective amount of oxycodone hydrochloride; and (ii) a gelling agent comprising starch, the gelling agent in an effective amount to impart a viscosity of at least about 10 cP to a solubilized mixture formed when the dosage form is subject to tampering by dissolution in from about 0.5 to about 10 ml of an aqueous liquid; wherein the weight ratio of the starch to the oxycodone hydrochloride is from less than 1:1 to about 1:3; and the dosage form provides an immediate release of the oxycodone hydrochloride when the dosage form is orally administered to a human patient.